Blocking Aging Enzyme 15-PGDH Triggers Cartilage Regrowth in Mice – A Stem-Cell-Free Regeneration Approach
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A recent study published in Science demonstrates that inhibiting the aging enzyme 15-PGDH can trigger cartilage regrowth in aged mice and induce early regeneration in human cartilage samples. Mice treated with a small-molecule inhibitor of 15-PGDH exhibited thickened, repaired cartilage across joints, producing hyaline cartilage rather than stiff fibrocartilage. Both systemic and intra-articular delivery methods proved effective, suggesting a regenerative approach to cartilage repair. These findings imply that cartilage loss, long considered irreversible, may be addressed by targeting aging-related enzymes, offering a potential non-surgical therapy for osteoarthritis. Human trials are necessary to confirm safety and efficacy.
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Key Entities
- • 15-PGDH enzyme - An aging-associated enzyme implicated in cartilage degradation.
- • Cartilage regeneration - The process of repairing or regrowing cartilage tissue.
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Source & Verification
Source: Lisboatv
Status: Confirmed
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